Improved immune responses in mice using the novel chitosan adjuvant ViscoGel, with a Haemophilus influenzae type b glycoconjugate vaccine

• Published in: Vaccine Vol. 29; no. 48; pp. 8965 - 8973
• Main Authors: Neimert-Andersson, Theresa, Hällgren, Anne-Charlotte, Andersson, Mats, Langebäck, Joakim, Zettergren, Louise, Nilsen-Nygaard, Julie, Draget, Kurt Ingar, van Hage, Marianne, Lindberg, Alf, Gafvelin, Guro, Grönlund, Hans
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 08.11.2011; Elsevier
• Subjects: Adjuvant; Adjuvants, Immunologic - administration & dosage; Allergy and Immunology; Animals; Antibodies, Bacterial - blood; Applied microbiology; Bacteriology; Biological and medical sciences; Cells, Cultured; Chitosan; Chitosan - administration & dosage; Chitosan - immunology; Cytokines - immunology; Female; Fundamental and applied biological sciences. Psychology; Haemophilus influenzae; Haemophilus Vaccines - administration & dosage; Haemophilus Vaccines - immunology; Immune response; Immunity, Cellular; Immunity, Humoral; Medicin och hälsovetenskap; Methylmethacrylates - administration & dosage; Mice; Mice, Inbred BALB C; Microbiology; Miscellaneous; Neutrophils; Neutrophils - immunology; Spleen - cytology; Spleen - immunology; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Conjugate - administration & dosage; Vaccines, Conjugate - immunology; Adjuvant; Immune response; Chitosan; Vaccination; Neutrophils; Rodentia; Polymer; Vaccine; Glycoconjugate; Haemophilus influenzae; Pasteurellaceae; Vertebrata; Mammalia; Mouse; Immunological adjuvant; Bacteria; Neutrophil
• ISSN: 0264-410X; 1873-2518; 1873-2518
• DOI: 10.1016/j.vaccine.2011.09.041

Highlights ► We have characterized a novel chitosan adjuvant. ► We have investigated the immune responses in mice. ► Neutrophils rapidly infiltrate the adjuvant. ► The humoral and cellular responses are enhanced.