Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease

• Published in: Frontiers in physiology Vol. 11; p. 593026
• Main Authors: Al-Bachari, Sarah, Naish, Josephine H., Parker, Geoff J. M., Emsley, Hedley C. A., Parkes, Laura M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 22.12.2020
• Subjects: blood–brain barrier; cerebrovascular disease; dynamic contrast enhanced MRI; neurovascular unit; Parkinson’s disease; Physiology; blood–brain barrier; cerebrovascular disease; dynamic contrast enhanced MRI; Parkinson’s disease; neurovascular unit
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2020.593026

Blood-brain barrier (BBB) disruption has been noted in animal models of Parkinson's disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking. To determine alterations in BBB integrity in PD, with comparison to cerebrovascular disease. Dynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects with cerebrovascular disease [control positive (CP)] and 31 healthy control subjects [control negative (CN)], with all groups matched for age. Quantitative maps of the contrast agent transfer coefficient across the BBB ( ) and plasma volume (v ) were produced using Patlak analysis. Differences in and v were assessed with voxel-based analysis as well as in regions associated with PD pathophysiology. In addition, the volume of white matter lesions (WMLs) was obtained from T -weighted fluid attenuation inversion recovery (FLAIR) images. Higher , reflecting higher BBB leakage, was found in the PD group than in the CN group using voxel-based analysis; differences were most prominent in the posterior white matter regions. Region of interest analysis confirmed to be significantly higher in PD than in CN, predominantly driven by differences in the substantia nigra, normal-appearing white matter, WML and the posterior cortex. WML volume was significantly higher in PD compared to CN. values and WML volume were similar in PD and CP, suggesting a similar burden of cerebrovascular disease despite lower cardiovascular risk factors. These results show BBB disruption in PD.