DNA breakage drives nuclear search

The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility r...

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Bibliographic Details
Published inNature cell biology Vol. 14; no. 5; pp. 448 - 450
Main Authors Ira, Grzegorz, Hastings, Philip J
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.05.2012
Subjects
Cell Cycle Proteins - physiology
Chromosomes
Chromosomes, Fungal
Deoxyribonucleic acid
DNA
DNA Damage
DNA repair
Enzymes
Genetic recombination
Genomes
Intracellular Signaling Peptides and Proteins - physiology
Kinases
Physiological aspects
Protein-Serine-Threonine Kinases - physiology
Proteins
Recombination, Genetic
Saccharomyces cerevisiae Proteins - physiology
Yeast
United States
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Summary:The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.
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ISSN:1465-7392
1476-4679
DOI:10.1038/ncb2494