Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Dogfish Adrenocorticotropic Hormone (Squalus acantias)

The nonatriacontapeptide corresponding to the entrie amino acid sequence of dogfish adrenocorticotropic hormone was synthesized by successive condensations of three peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-NHNH2 and Z-(1-10)-OH, with H-(20-39)-OBzl, a synthetic intermediate of dogfish...

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Published inChemical & pharmaceutical bulletin Vol. 27; no. 2; pp. 499 - 507
Main Authors OKAMOTO, KENJI, YASUMURA, KOICHI, SHIMAMURA, SHINICHI, NAKAMURA, MASUHISA, TANAKA, AKIRA, YAJIMA, HARUAKI
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1979
Japan Science and Technology Agency
Subjects
Adrenocorticotropic Hormone - chemical synthesis
Amino Acid Sequence
Animals
Dogfish - metabolism
in vivo steroidogenetic activity
Sharks - metabolism
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Summary:The nonatriacontapeptide corresponding to the entrie amino acid sequence of dogfish adrenocorticotropic hormone was synthesized by successive condensations of three peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-NHNH2 and Z-(1-10)-OH, with H-(20-39)-OBzl, a synthetic intermediate of dogfish corticotropin-like intermediate lobe peptide. The synthetic peptide exhibited the in vivo steroidogenetic activity of 21.3 IU/mg.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.27.499