Transdermal Estrogen Therapy Improves Gains in Skeletal Muscle Mass After 12 Weeks of Resistance Training in Early Postmenopausal Women
Women show an accelerated loss of muscle mass around menopause, possibly related to the decline in estrogen. Furthermore, the anabolic response to resistance exercise seems to be hampered in postmenopausal women. We aimed to test the hypothesis that transdermal estrogen therapy (ET) amplifies the sk...
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Published in | Frontiers in physiology Vol. 11; p. 596130 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
18.01.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Women show an accelerated loss of muscle mass around menopause, possibly related to the decline in estrogen. Furthermore, the anabolic response to resistance exercise seems to be hampered in postmenopausal women.
We aimed to test the hypothesis that transdermal estrogen therapy (ET) amplifies the skeletal muscle response to resistance training in early postmenopausal women.
A double-blinded randomized controlled study.
Department of Public Health, Aarhus University, Denmark.
Thirty-one healthy, untrained postmenopausal women no more than 5 years past menopause.
Supervised resistance training with placebo (PLC,
= 16) or transdermal ET (
= 15) for 12 weeks.
The primary outcome parameter was a cross-sectional area of quadriceps femoris measured by magnetic resonance imaging, and secondary parameters were fat-free mass (dual-energy X-ray absorptiometry), muscle strength, and functional tests.
The increase in muscle cross-sectional area was significantly greater in the ET group (7.9%) compared with the PLC group (3.9%) (
< 0.05). Similarly, the increase in whole-body fat-free mass was greater in the ET group (5.5%) than in the PLC group (2.9%) (
< 0.05). Handgrip strength increased in ET (
< 0.05) but did not change in the PLC group. Muscle strength parameters, jumping height, and finger strength were all improved after the training period with no difference between groups.
The use of transdermal ET enhanced the increase in muscle mass in response to 12 weeks of progressive resistance training in early postmenopausal women. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Xu Yan, Victoria University, Australia; Ashril Yusof, University of Malaya, Malaysia This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology Edited by: David Cameron-Smith, Singapore Institute for Clinical Sciences (A∗STAR), Singapore |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2020.596130 |