Correlation between scalp-recorded electroencephalographic and electrocorticographic activities during ictal period

• Published in: Seizure (London, England) Vol. 16; no. 3; pp. 238 - 247
• Main Authors: Hashiguchi, Kimiaki, Morioka, Takato, Yoshida, Fumiaki, Miyagi, Yasushi, Nagata, Shinji, Sakata, Ayumi, Sasaki, Tomio
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2007
• Subjects: Adolescent; Adult; Electrocorticography; Electrodes, Implanted; Electroencephalography - methods; Epilepsies, Partial - diagnosis; Epilepsies, Partial - physiopathology; Female; Humans; Ictal electroencephalography; Male; Middle Aged; Neurology; Partial epilepsy; Pyramidal Cells - physiopathology; Seizures - physiopathology; Partial epilepsy; Ictal electroencephalography; Electrocorticography
• ISSN: 1059-1311; 1532-2688
• DOI: 10.1016/j.seizure.2006.12.010

Summary Objective To investigate the correlation between scalp-recorded electroencephalographic (EEG) and electrocorticographic (ECoG) activities during ictal periods. Methods Simultaneous EEG and ECoG recordings with chronic subdural electrodes were performed in eight patients with partial epilepsy. Results In two cases where the ictal ECoG discharges originated in deep brain structures such as the hippocampus and interhemispheric surface of the frontal lobe, ictal discharges could not be detected on EEG until they expanded to the cortex of convexity. In four cases, the ictal onset zones were located in the lateral convexity. When synchronous or near synchronous ictal ECoG discharges with amplitudes of 200–2000 μV were recorded on more than 8–15 cm2 of cortex, corresponding discharges were recorded on EEG in these four cases. However, in a case of frontal lobe epilepsy, asynchronous ictal ECoG discharges were recorded on 10 electrodes of convexity but no ictal EEG activity was recorded. Furthermore, in two frontal lobe epilepsy cases, ictal EEG discharges did not always reflect the ictal ECoG spike, but occasionally reflected slow background ECoG activity around the ictal discharges. Conclusions Multiple factors such as the width of the cortical area involved, amplitude of ictal discharges and degree of synchronization of electrical potentials play important roles in the appearance of ictal EEG recordings, and the relationship between ictal EEG and ECoG is not straightforward.