Virulence Factors in Hypervirulent Klebsiella pneumoniae

Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver ab...

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Published inFrontiers in microbiology Vol. 12; p. 642484
Main Authors Zhu, Jie, Wang, Tao, Chen, Liang, Du, Hong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.04.2021
Subjects
capsule
hypermucoviscous
hypervirulence
Klebsiella pneumoniae
Microbiology
siderophores
virulence factors
hypervirulence
capsule
hypermucoviscous
siderophores
Klebsiella pneumoniae
virulence factors
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Summary:Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.
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Edited by: Axel Cloeckaert, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), France
Reviewed by: Ning Dong, City University of Hong Kong, Hong Kong; David A. Rosen, Washington University in St. Louis, United States; Balaji Veeraraghavan, Christian Medical College & Hospital, India
This article was submitted to Infectious Diseases, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.642484