The Role of the Bone Marrow Microenvironment in the Response to Infection

Hematopoiesis in the bone marrow (BM) is the primary source of immune cells. Hematopoiesis is regulated by a diverse cellular microenvironment that supports stepwise differentiation of multipotent stem cells and progenitors into mature blood cells. Blood cell production is not static and the bone ma...

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Published inFrontiers in immunology Vol. 11; p. 585402
Main Authors Johnson, Courtney B, Zhang, Jizhou, Lucas, Daniel
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 25.11.2020
Subjects
bone marrow
hematopoiesis
Immunology
infection
microenvironment
niche
microenvironment
hematopoiesis
infection
niche
bone marrow
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Summary:Hematopoiesis in the bone marrow (BM) is the primary source of immune cells. Hematopoiesis is regulated by a diverse cellular microenvironment that supports stepwise differentiation of multipotent stem cells and progenitors into mature blood cells. Blood cell production is not static and the bone marrow has evolved to sense and respond to infection by rapidly generating immune cells that are quickly released into the circulation to replenish those that are consumed in the periphery. Unfortunately, infection also has deleterious effects injuring hematopoietic stem cells (HSC), inefficient hematopoiesis, and remodeling and destruction of the microenvironment. Despite its central role in immunity, the role of the microenvironment in the response to infection has not been systematically investigated. Here we summarize the key experimental evidence demonstrating a critical role of the bone marrow microenvironment in orchestrating the bone marrow response to infection and discuss areas of future research.
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This article was submitted to Immunological Tolerance and Regulation, a section of the journal Frontiers in Immunology
Reviewed by: Yoko Hamazaki, Kyoto University, Japan; Kenneth Beaman, Rosalind Franklin University of Medicine and Science, United States
Edited by: César Nombela Arrieta, University of Zurich, Switzerland
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.585402