From planta to pharma with glycosylation in the toolbox

Plant-specific glycosylation has long been a major limitation to the extensive use of plant-made pharmaceuticals in human therapy. Our goal here is to highlight the progress recently made towards humanization of N -glycosylation in plants and to illustrate that plant-typical N - and O -glycosylation...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 25; no. 7; pp. 317 - 323
Main Authors Saint-Jore-Dupas, Claude, Faye, Loïc, Gomord, Véronique
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.07.2007
Elsevier Science
Elsevier Limited
Subjects
Advantages
Biological activity
Biological and medical sciences
biopharmaceuticals
Biotechnology
Efficiency
Fundamental and applied biological sciences. Psychology
gene expression
Glycoproteins
Glycosylation
Glycosyltransferases - metabolism
Growth hormones
Internal Medicine
literature reviews
Mammals
N-glycosylation
O-glycosylation
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Plants - chemistry
Plants - metabolism
Plants, Genetically Modified - metabolism
Polysaccharides - biosynthesis
Polysaccharides - chemistry
Polysaccharides - genetics
Polysaccharides - metabolism
post-translational modification
protein synthesis
Proteins
recombinant proteins
Sugar
transgenes
transgenic plants
Drug
Glycosylation
Transgenic plant
Review
Recombinant protein
Biopharmaceuticals
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Summary:Plant-specific glycosylation has long been a major limitation to the extensive use of plant-made pharmaceuticals in human therapy. Our goal here is to highlight the progress recently made towards humanization of N -glycosylation in plants and to illustrate that plant-typical N - and O -glycosylation progressively emerge as additional advantages for using this promising expression system.
Bibliography:http://dx.doi.org/10.1016/j.tibtech.2007.04.008
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ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2007.04.008