The Adipocyte and Adaptive Immunity

Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes. The adaptive immune response consis...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 11; p. 593058
Main Authors Song, Jianfeng, Deng, Tuo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 27.11.2020
Subjects
adaptive immunity
adipocyte
adipokine
B cell
Immunology
T cell
B cell
adipokine
T cell
adaptive immunity
adipocyte
Online AccessGet full text

Cover

More Information
Summary:Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes. The adaptive immune response consists of T cell-mediated cellular immunity and B cell-mediated humoral immunity. Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 T cells. In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. Adipokines are also involved in B cell generation, development, activation, and antibody production. Therefore, adipocytes play an important role in B cell-mediated adaptive immunity. This review describes how adipocytes participate in adaptive immunity from the perspective of T cells and B cells, and discusses their role in the pathogenesis of various diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
This article was submitted to Immunological Tolerance and Regulation, a section of the journal Frontiers in Immunology
Reviewed by: David Bradley, The Ohio State University, United States; Aimin Xu, The University of Hong Kong, Hong Kong
Edited by: Willa Ann Hsueh, The Ohio State University, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.593058