Currently Available Strategies for Target Identification of Bioactive Natural Products

In recent years, biologically active natural products have gradually become important agents in the field of drug research and development because of their wide availability and variety. However, the target sites of many natural products are yet to be identified, which is a setback in the pharmaceut...

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Published inFrontiers in chemistry Vol. 9; p. 761609
Main Authors Li, Gen, Peng, Xuling, Guo, Yajing, Gong, Shaoxuan, Cao, Shijie, Qiu, Feng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 30.09.2021
Subjects
Chemistry
drug discovery
natural product
non-probe
probe
target identification
non-probe
drug discovery
natural product
target identification
probe
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Summary:In recent years, biologically active natural products have gradually become important agents in the field of drug research and development because of their wide availability and variety. However, the target sites of many natural products are yet to be identified, which is a setback in the pharmaceutical industry and has seriously hindered the translation of research findings of these natural products as viable candidates for new drug exploitation. This review systematically describes the commonly used strategies for target identification via the application of probe and non-probe approaches. The merits and demerits of each method were summarized using recent examples, with the goal of comparing currently available methods and selecting the optimum techniques for identifying the targets of bioactive natural products.
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Edited by: Cheng-Peng Sun, Dalian Medical University, China
Wufu Zhu, Jiangxi Science and Technology Normal University, China
These authors have contributed equally to this work
This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry
Reviewed by: Qingbin Cui, University of Toledo, United States
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.761609