The role of TREX in gene expression and disease

TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway. In additi...

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Bibliographic Details
Published inBiochemical journal Vol. 473; no. 19; p. 2911
Main Authors Heath, Catherine G, Viphakone, Nicolas, Wilson, Stuart A
Format Journal Article
LanguageEnglish
Published England 01.10.2016
Subjects
Biological Transport
DNA Damage
Gene Expression
Humans
RNA Processing, Post-Transcriptional
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcription Factors - physiology
NXF1
mRNA export
THO
transport
RNA processing
nucleocytoplasmic
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Summary:TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway. In addition, this complex prevents DNA damage and regulates the cell cycle by ensuring optimal gene expression. As the extent of TREX activity in viral infections, amyotrophic lateral sclerosis and cancer emerges, the need for a greater understanding of TREX function becomes evident. A complete elucidation of the composition, function and interactions of the complex will provide the framework for understanding the molecular basis for a variety of diseases. This review details the known composition of TREX, how it is regulated and its cellular functions with an emphasis on mammalian systems.
ISSN:1470-8728
DOI:10.1042/bcj20160010