International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

• Published in: Pharmacological reviews Vol. 73; no. 1; pp. 310 - 520
• Main Authors: Barnes, Nicholas M, Ahern, Gerard P, Becamel, Carine, Bockaert, Joël, Camilleri, Michael, Chaumont-Dubel, Severine, Claeysen, Sylvie, Cunningham, Kathryn A, Fone, Kevin C, Gershon, Michael, Di Giovanni, Giuseppe, Goodfellow, Nathalie M, Halberstadt, Adam L, Hartley, Rachel M, Hassaine, Ghérici, Herrick-Davis, Katharine, Hovius, Ruud, Lacivita, Enza, Lambe, Evelyn K, Leopoldo, Marcello, Levy, Finn Olav, Lummis, Sarah C R, Marin, Philippe, Maroteaux, Luc, McCreary, Andrew C, Nelson, David L, Neumaier, John F, Newman-Tancredi, Adrian, Nury, Hugues, Roberts, Alexander, Roth, Bryan L, Roumier, Anne, Sanger, Gareth J, Teitler, Milt, Sharp, Trevor, Villalón, Carlos M, Vogel, Horst, Watts, Stephanie W, Hoyer, Daniel
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.01.2021; The American Society for Pharmacology and Exper imental Therapeutics
• Subjects: Animal genetics; Biochemistry, Molecular Biology; Cardiology and cardiovascular system; Genetics; Human health and pathology; Humans; IUPHAR Nomenclature Report; Life Sciences; Ligands; Molecular biology; Neurobiology; Neurons and Cognition; Pharmaceutical sciences; Pharmacology; Pharmacology, Clinical; Psychiatrics and mental health; Pulmonology and respiratory tract; Receptors, Serotonin; Serotonin
• ISSN: 0031-6997; 1521-0081; 1521-0081
• DOI: 10.1124/pr.118.015552

5-HT receptors expressed throughout the human body are targets for established therapeutics and various drugs in development. Their diversity of structure and function reflects the important role 5-HT receptors play in physiologic and pathophysiological processes. The present review offers a framework for the official receptor nomenclature and a detailed understanding of each of the 14 5-HT receptor subtypes, their roles in the systems of the body, and, where appropriate, the (potential) utility of therapeutics targeting these receptors. SIGNIFICANCE STATEMENT: This review provides a comprehensive account of the classification and function of 5-hydroxytryptamine receptors, including how they are targeted for therapeutic benefit.