Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats

• Published in: Neuroscience Vol. 252; pp. 396 - 409
• Main Authors: Cervantes-Durán, C, Rocha-González, H.I, Granados-Soto, V
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 12.11.2013; Elsevier
• Subjects: 5-HT receptors; Animals; Biological and medical sciences; Female; fluoxetine; Fluoxetine - pharmacology; formalin test; Fundamental and applied biological sciences. Psychology; mechanism of action; Neurology; nociception; Pain - metabolism; Peripheral Nervous System - drug effects; Peripheral Nervous System - metabolism; Rats; Rats, Wistar; Receptors, Serotonin - metabolism; Serotonin Antagonists - pharmacology; Serotonin Uptake Inhibitors - pharmacology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Spinal Cord - drug effects; Spinal Cord - metabolism; Vertebrates: nervous system and sense organs; [1-[2-methylsulphonylamino ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate; 4-(3-chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride; SSRIs; 5-hydroxytryptamine; 3-(2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione(+)tartrate; N-[2-(dimethylamino)ethyl]- N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride; GR-127935; 5-HT receptors; AUC; fluoxetine; area under the number of flinches against time curves; GR-113808; RS-102221; ANOVA; RS-127445; selective serotonin reuptake inhibitors; 1′-methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3- f]indole-3,4′-piperidine hydrochloride; SB-224289; one-way analysis of variance; SB-699551; (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol hydrochloride; SB-269970; mechanism of action; nociception; WAY-100635; N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate; BRL-15572; N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1′-biphenyl-4-carboxamide hydrochloride hydrate; SB-258585; dorsal root ganglion; DRG; 8-[5-(2,4-dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]1,3,8-triazaspiro[4.5] decane-2,4-dione hydrochloride; 5-HT; 4-iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzene-sulfonamide hydrochloride; formalin test; Nociception; Analgesia; Vertebrata; Mammalia; Rat; Fluoxetine; Animal; Rodentia; Serotonine receptor; N-[2-(dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride; 1′-methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4′-piperidine hydrochloride
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.08.022

Highlights • Fluoxetine produces local nociception and spinal antinociception. • Fluoxetine-induced nociception was prevented by 5-HT2A/2B/2C/3/4/6/7 antagonists. • Fluoxetine-induced nociception was unaltered by 5-HT1A/1B/1D/5A antagonists. • Fluoxetine-induced antinociception was prevented by 5-HT1A/1B/1D/5A antagonists. • Fluoxetine-induced antinociception was unaltered by 5-HT2/3/4/6/7 antagonists.