Understanding the role of wild ruminants in anthelmintic resistance in livestock

Wild ruminants are susceptible to infection from generalist helminth species, which can also infect domestic ruminants. A better understanding is required of the conditions under which wild ruminants can act as a source of helminths (including anthelmintic-resistant genotypes) for domestic ruminants...

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Published inBiology letters (2005) Vol. 18; no. 5; p. 20220057
Main Authors Brown, Tony L, Airs, Paul M, Porter, Siobhán, Caplat, Paul, Morgan, Eric R
Format Journal Article
LanguageEnglish
Published England The Royal Society 04.05.2022
Subjects
Animals
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
Drug Resistance - genetics
Haemonchus - genetics
Livestock
Pathogen Biology
Review
Ruminants
deer
Haemonchus contortus
transmission
nematodes
refugia
trematodes
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Summary:Wild ruminants are susceptible to infection from generalist helminth species, which can also infect domestic ruminants. A better understanding is required of the conditions under which wild ruminants can act as a source of helminths (including anthelmintic-resistant genotypes) for domestic ruminants, and vice versa, with the added possibility that wildlife could act as for drug-susceptible genotypes and hence buffer the spread and development of resistance. Helminth infections cause significant productivity losses in domestic ruminants and a growing resistance to all classes of anthelmintic drug escalates concerns around helminth infection in the livestock industry. Previous research demonstrates that drug-resistant strains of the pathogenic nematode can be transmitted between wild and domestic ruminants, and that gastro-intestinal nematode infections are more intense in wild ruminants within areas of high livestock density. In this article, the factors likely to influence the role of wild ruminants in helminth infections and anthelmintic resistance in livestock are considered, including host population movement across heterogeneous landscapes, and the effects of climate and environment on parasite dynamics. Methods of predicting and validating suspected drivers of helminth transmission in this context are considered based on advances in predictive modelling and molecular tools.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1744-957X
1744-9561
1744-957X
DOI:10.1098/rsbl.2022.0057