The Roles of Inflammation in Keloid and Hypertrophic Scars

The underlying mechanisms of wound healing are complex but inflammation is one of the determining factors. Besides its traditional role in combating against infection upon injury, the characteristics and magnitude of inflammation have dramatic impacts on the pathogenesis of scar. Keloids and hypertr...

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Published inFrontiers in immunology Vol. 11; p. 603187
Main Authors Wang, Zheng-Cai, Zhao, Wan-Yi, Cao, Yangyang, Liu, Yan-Qi, Sun, Qihang, Shi, Peng, Cai, Jia-Qin, Shen, Xiao Z., Tan, Wei-Qiang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 04.12.2020
Subjects
hypertrophic scar
immune cells
Immunology
inflammatory mediators
keloid
potential therapeutics
signal transduction pathways
inflammatory mediators
keloid
immune cells
hypertrophic scar
potential therapeutics
signal transduction pathways
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Summary:The underlying mechanisms of wound healing are complex but inflammation is one of the determining factors. Besides its traditional role in combating against infection upon injury, the characteristics and magnitude of inflammation have dramatic impacts on the pathogenesis of scar. Keloids and hypertrophic scars are pathological scars that result from aberrant wound healing. They are characterized by continuous local inflammation and excessive collagen deposition. In this review, we aim at discussing how dysregulated inflammation contributes to the pathogenesis of scar formation. Immune cells, soluble inflammatory mediators, and the related intracellular signal transduction pathways are our three subtopics encompassing the events occurring in inflammation associated with scar formation. In the end, we enumerate the current and potential medicines and therapeutics for suppressing inflammation and limiting progression to scar. Understanding the initiation, progression, and resolution of inflammation will provide insights into the mechanisms of scar formation and is useful for developing effective treatments.
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Edited by: Allison Cowin, University of South Australia, Australia
This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Andrew William Stevenson, University of Western Australia, Australia; Zlatko Kopecki, University of South Australia, Australia
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.603187