Prosthetic Valve Endocarditis Caused by ST8 SCCmecIVl Type Community-associated Methicillin-resistant Staphylococcus aureus

• Published in: Internal Medicine Vol. 58; no. 5; pp. 743 - 747
• Main Authors: Kitagawa, Hiroki, Ohge, Hiroki, Hisatsune, Junzo, Kajihara, Toshiki, Katayama, Keijiro, Takahashi, Shinya, Sueda, Taijiro, Sugai, Motoyuki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.03.2019; Japan Science and Technology Agency
• Subjects: Case Report; Colon cancer; community-associated methicillin-resistant Staphylococcus aureus; Drug resistance; Endocarditis; Heart surgery; infectious endocarditis; Internal medicine; Methicillin; Mitral valve; multilocus sequence; Penicillin; Prostheses; Septic shock; Staphylococcal enterotoxin F; Staphylococcus aureus; Staphylococcus infections; Toxic shock syndrome; infectious endocarditis; multilocus sequence; septic shock; community-associated methicillin-resistant Staphylococcus aureus
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.1415-18

The emergence of a Japan-intrinsic community associated methicillin-resistant Staphylococcus aureus strain (CA-MRSA/J) has been reported. A 70-year-old man with recurrent colon cancer and a history of mitral valve replacement was admitted to the hospital in a state of shock. He was diagnosed with prosthetic valve endocarditis (PVE) caused by MRSA and underwent cardiac surgery. The MRSA isolates belonged to multilocus sequence type 8 and carried staphylococcal cassette chromosome mec IVl and the genes of toxic shock syndrome toxin-1, enterotoxin C, and enterotoxin L. These characteristics indicated a CA-MRSA/J clone. This is the first reported case of PVE caused by CA-MRSA/J.