Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells

• Published in: Journal of natural medicines Vol. 70; no. 3; pp. 661 - 666
• Main Authors: Amen, Yhiya M., Zhu, Qinchang, Tran, Hai-Bang, Afifi, Mohamed S., Halim, Ahmed F., Ashour, Ahmed, Mira, Amira, Shimizu, Kuniyoshi
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.07.2016
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Line, Tumor; Complementary & Alternative Medicine; Drugs, Chinese Herbal - therapeutic use; Ganoderma - chemistry; HeLa Cells; Humans; Lanosterol - analogs & derivatives; Lanosterol - chemistry; Medicinal Chemistry; Neoplasms - drug therapy; Pharmacology/Toxicology; Pharmacy; Plant Sciences; Reishi - chemistry; Cytotoxic; Lucidumol C; Ganoderma
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-016-0976-2

A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi . Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compounds were evaluated against human colorectal carcinoma (HCT-116, Caco-2), human liver carcinoma (HepG2), and human cervical carcinoma (HeLa) cell lines using WST-1 reagent. Selectivity was evaluated using normal human fibroblast cells (TIG-1 and HF19). Among the compounds, lucidumol C showed potent selective cytotoxicity against HCT-116 cells with an IC 50 value of 7.86 ± 4.56 µM and selectivity index (SI) >10 with remarkable cytotoxic activities against Caco-2, HepG2 and HeLa cell lines.