Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure. Overexpression of ATP binding cassette (ABC) transpor...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in pharmacology Vol. 12; p. 648407
Main Authors Xiao, Huan, Zheng, Yongcheng, Ma, Lingling, Tian, Lili, Sun, Qiu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.04.2021
Subjects
ABCB1
ABCC1
ABCG2
anti-cancer
MDR
Pharmacology
ABCC1
MDR
ABCB1
anti-cancer
ABCG2
Online AccessGet full text

Cover

More Information
Summary:Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad spectrum of structurally and mechanistically unrelated drugs across membranes, severely impairs the response to chemotherapy and leads to chemotherapy failure. Overexpression of ATP binding cassette (ABC) transporters is a major contributing factor resulting in MDR, which can recognize and mediate the efflux of diverse drugs from cancer cells, thereby decreasing intracellular drug concentration. Therefore, modulators of ABC transporter could be used in combination with standard chemotherapeutic anticancer drugs to augment the therapeutic efficacy. This review summarizes the recent advances of important cancer-related ABC transporters, focusing on their physiological functions, structures, and the development of new compounds as ABC transporter inhibitors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Guozheng Huang, Anhui University of Technology, China
This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology
Edited by: Caiyun Fu, Zhejiang Sci-Tech University, China
These authors have have contributed equally to this work and share first authorship
Xiao-Feng Xiong, Sun Yat-Sen University, China
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.648407