Multitasking dynamic contrast enhanced magnetic resonance imaging can accurately differentiate chronic pancreatitis from pancreatic ductal adenocarcinoma

• Published in: Frontiers in oncology Vol. 12; p. 1007134
• Main Authors: Wang, Nan, Gaddam, Srinivas, Xie, Yibin, Christodoulou, Anthony G., Wu, Chaowei, Ma, Sen, Fan, Zhaoyang, Wang, Lixia, Lo, Simon, Hendifar, Andrew E., Pandol, Stephen J., Li, Debiao
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.01.2023
• Subjects: differential diagnosis of chronic pancreatitis and pancreatic ductal adenocarcinoma; dynamic contrast enhanced magnetic resonance imaging; microcirculation properties; Multitasking DCE; Oncology; quantitative imaging; quantitative imaging; microcirculation properties; Multitasking DCE; dynamic contrast enhanced magnetic resonance imaging; differential diagnosis of chronic pancreatitis and pancreatic ductal adenocarcinoma
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2022.1007134

Accurate differentiation of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is an area of unmet clinical need. In this study, a novel Multitasking dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) technique was used to quantitatively evaluate the microcirculation properties of pancreas in CP and PDAC and differentiate between them. The Multitasking DCE technique was able to acquire one 3D image per second during the passage of MRI contrast agent, allowing the quantitative estimation of microcirculation properties of tissue, including blood flow F , plasma volume fraction v , transfer constant K , and extravascular extracellular volume fraction v . Receiver operating characteristic (ROC) analysis was performed to differentiate the CP pancreas, PDAC pancreas, normal control pancreas, PDAC tumor, PDAC upstream, and PDAC downstream. ROCs from quantitative analysis and conventional analysis were compared. Fourteen PDAC patients, 8 CP patients and 20 healthy subjects were prospectively recruited. The combination of F , v , K , and v can differentiate CP versus PDAC pancreas with good AUC (AUC [95% CI] = 0.821 [0.654 - 0.988]), CP versus normal pancreas with excellent AUC (1.000 [1.000 - 1.000]), PDAC pancreas versus normal pancreas with excellent AUC (1.000 [1.000 - 1.000]), CP versus PDAC tumor with excellent AUC (1.000 [1.000 - 1.000]), CP versus PDAC downstream with excellent AUC (0.917 [0.795 - 1.000]), and CP versus PDAC upstream with fair AUC (0.722 [0.465 - 0.980]). This quantitative analysis outperformed conventional analysis in differentiation of each pair. Multitasking DCE MRI is a promising clinical tool that is capable of unbiased quantitative differentiation between CP from PDAC.