Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function

• Published in: Frontiers in immunology Vol. 11; p. 586613
• Main Authors: Zhu, Bo, Zhu, Lihua, Xia, Lin, Xiong, Yuyun, Yin, Qing, Rui, Ke
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.11.2020
• Subjects: DC maturation; dendritic cells; immune responses; Immunology; post-translational modification; ubiquitination; dendritic cells; post-translational modification; DC maturation; ubiquitination; immune responses
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2020.586613

Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process that has emerged as a crucial mechanism that regulates DC maturation and function. Recent studies have shown that ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are pivotal regulators of DC-mediated immune function and serve as potential targets for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, infections, and tumors). In this review, we summarize the recent progress regarding the molecular mechanisms and function of ubiquitination in DC-mediated immune homeostasis and immune response.