Immunomodulatory Effects of Histone Deacetylation Inhibitors in Graft-vs.-Host Disease After Allogeneic Stem Cell Transplantation

Histone deacetylase inhibitors are currently the most studied drugs because of their beneficial effects on inflammatory response. Emerging data from numerous basic studies and clinical trials have shown that histone deacetylase inhibitors can suppress immune-mediated diseases, such as graft-vs.-host...

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Published inFrontiers in immunology Vol. 12; p. 641910
Main Authors Xu, Xiaoxiao, Li, Xiaoqin, Zhao, Yanmin, Huang, He
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.02.2021
Subjects
allo-reactive T cells
allogeneic hematopoietic stem cell transplantation
epigenetic regulation
graft-vs.-host disease
histone deacetylase inhibitors
Immunology
graft-vs.-host disease
allo-reactive T cells
epigenetic regulation
allogeneic hematopoietic stem cell transplantation
histone deacetylase inhibitors
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Summary:Histone deacetylase inhibitors are currently the most studied drugs because of their beneficial effects on inflammatory response. Emerging data from numerous basic studies and clinical trials have shown that histone deacetylase inhibitors can suppress immune-mediated diseases, such as graft-vs.-host disease (GVHD), while retaining beneficial graft-vs.-leukemia (GVL) effects. These drugs prevent and/or treat GVHD by modifying gene expression and inhibiting the production of proinflammatory cytokines, regulating the function of alloreactive T cells, and upregulating the function and number of regulatory T cells. Some of these drugs may become new immunotherapies for GVHD and other immune diseases.
Bibliography:ObjectType-Article-2
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Edited by: Michaela Lucas, University of Western Australia, Australia
Reviewed by: Benny Chen, Duke University, United States; Honglin Wang, Shanghai Jiao Tong University, China
This article was submitted to Alloimmunity and Transplantation, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.641910