Heparin Therapy Improving Hypoxia in COVID-19 Patients - A Case Series
Elevated D-dimer is a predictor of severity and mortality in COVID-19 patients, and heparin use during in-hospital stay has been associated with decreased mortality. COVID-19 patient autopsies have revealed thrombi in the microvasculature, suggesting that hypercoagulability is a prominent feature of...
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Published in | Frontiers in physiology Vol. 11; p. 573044 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
19.10.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Elevated D-dimer is a predictor of severity and mortality in COVID-19 patients, and heparin use during in-hospital stay has been associated with decreased mortality. COVID-19 patient autopsies have revealed thrombi in the microvasculature, suggesting that hypercoagulability is a prominent feature of organ failure in these patients. Interestingly, in COVID-19, pulmonary compliance is preserved despite severe hypoxemia corroborating the hypothesis that perfusion mismatch may play a significant role in the development of respiratory failure.
We describe a series of 27 consecutive COVID-19 patients admitted to Sirio-Libanes Hospital in São Paulo-Brazil and treated with heparin in therapeutic doses tailored to clinical severity.
PaO2/FiO2 ratio increased significantly over the 72 h following the start of anticoagulation, from 254(±90) to 325(±80),
= 0.013, and 92% of the patients were discharged home within a median time of 11 days. There were no bleeding complications or fatal events.
Even though this uncontrolled case series does not offer absolute proof that micro thrombosis in the pulmonary circulation is the underlying mechanism of respiratory failure in COVID-19, patient's positive response to heparinization contributes to the understanding of the pathophysiological mechanism of the disease and provides valuable information for the treatment of these patients while we await the results of further prospective controlled studies. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ORCID: Bruna Mamprim Piloto, orcid.org/0000-0002-8756-0400; Luciana Kato Morinaga, orcid.org/0000-0002-0900-2737; Carlos Viana Poyares Jardim, orcid.org/0000-0003-0425-5548; Shari Anne El-Dash Lamy, orcid.org/0000-0003-2915-4014; Marcelo Alves Ferreira, orcid.org/0000-0003-4181-760X; Elbio Antonio D’Amico, orcid.org/0000-0003-1069-1469; Daniel Deheinzelin, orcid.org/0000-0002-0253-4124 This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Reviewed by: Melissa L. Bates, The University of Iowa, United States; Marli Maria Knorst, Federal University of Rio Grande do Sul, Brazil Edited by: Georges Leftheriotis, Université Côte d’Azur, France |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2020.573044 |