Association between triglyceride glucose index and arterial stiffness in Korean adults

• Published in: Cardiovascular diabetology Vol. 17; no. 1; pp. 41 - 6
• Main Authors: Lee, Sang Bae, Ahn, Chul Woo, Lee, Byoung Kwon, Kang, Shinae, Nam, Ji Sun, You, Ji Hong, Kim, Min Jin, Kim, Min Kyung, Park, Jong Suk
• Format: Journal Article
• Language: English
• Published: England BioMed Central 21.03.2018; BMC
• Subjects: Adult; Ankle Brachial Index; Arterial stiffness; Biomarkers - blood; Blood Glucose - analysis; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - physiopathology; Cross-Sectional Studies; Female; Glucose Metabolism Disorders - blood; Glucose Metabolism Disorders - diagnosis; Glucose Metabolism Disorders - epidemiology; Humans; Insulin Resistance; Male; Middle Aged; Original Investigation; Pulse Wave Analysis; Pulse wave velocity; Risk Assessment; Risk Factors; Seoul - epidemiology; Triglyceride glucose index; Triglycerides - blood; Vascular Stiffness; Seoul; Pulse wave velocity; Triglyceride glucose index; Insulin resistance; Arterial stiffness
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-018-0692-1

The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffness in adults. Therefore, we evaluated the relationship between the TyG index and arterial stiffness as measured based on brachial ankle pulse wave velocity (baPWV) in Korean adults. A total of 3587 subjects were enrolled in this study. Anthropometric and cardiovascular risk factors were measured. The TyG index was calculated as ln[fasting triglycerides(mg/dl) × fasting glucose(mg/dl)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. Arterial stiffness was determined by measuring baPWV. The subjects were stratified into four groups based on the TyG index. There were significant differences in cardiovascular parameters among the groups; the mean baPWV increased significantly with increasing TyG index. According to the logistic regression analysis after adjusting for multiple risk factors, the odds ratio (95% CI) for increased baPWV (> 75th percentile) for the highest and lowest quartiles of the TyG index was 2.92 (1.92-4.44) in men and 1.84 (1.15-2.96) in women, and the odds ratio for increased baPWV for the highest and lowest quartiles of the HOMA-IR was 1.80 (1.17-2.78) in men and 1.46 (1.06-2.47) in women, respectively. The TyG index is more independently associated with increased arterial stiffness than HOMA-IR in Korean adults.