Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-...

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Published inFrontiers in microbiology Vol. 12; p. 737288
Main Authors Nishino, Kunihiko, Yamasaki, Seiji, Nakashima, Ryosuke, Zwama, Martijn, Hayashi-Nishino, Mitsuko
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.12.2021
Subjects
drug resistance
Gram-negative bacteria
inhibitor
Microbiology
multidrug efflux pumps
regulation
multidrug efflux pumps
Gram-negative bacteria
drug resistance
inhibitor
regulation
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Summary:Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Reviewed by: Aixin Yan, The University of Hong Kong, Hong Kong SAR, China; Sujeet Kumar, The Ohio State University, United States
Edited by: Hidetada Hirakawa, Gunma University, Japan
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.737288