TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses

• Published in: Frontiers in immunology Vol. 11; p. 608976
• Main Authors: Xu, Yan-Ran, Lei, Cao-Qi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.01.2021
• Subjects: Immunology; inflammation; NF-κB; post-translational modifications; TABs; TAK1; NF-κB; TABs; post-translational modifications; TAK1; inflammation

Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding protein...