TAK1-TABs Complex: A Central Signalosome in Inflammatory Responses

Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding protein...

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Published inFrontiers in immunology Vol. 11; p. 608976
Main Authors Xu, Yan-Ran, Lei, Cao-Qi
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 05.01.2021
Subjects
Immunology
inflammation
NF-κB
post-translational modifications
TABs
TAK1
NF-κB
TABs
post-translational modifications
TAK1
inflammation
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Summary:Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of physiological and pathological processes. TAK1 functions through assembling with its binding partners TAK1-binding proteins (TAB1, TAB2, and TAB3) and can be activated by a variety of stimuli such as tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and toll-like receptor ligands, and they play essential roles in the activation of NF-κB and MAPKs. Numerous studies have demonstrated that post-translational modifications play important roles in properly controlling the activity, stability, and assembly of TAK1-TABs complex according to the indicated cellular environment. This review focuses on the recent advances in TAK1-TABs-mediated signaling and the regulations of TAK1-TABs complex by post-translational modifications.
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This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Neil J. Grimsey, University of Georgia, United States; Jae Hyuck Shim, University of Massachusetts Medical School, United States
Edited by: Massimo Gadina, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.608976