Translational Control by Ribosome Pausing in Bacteria: How a Non-uniform Pace of Translation Affects Protein Production and Folding

Protein homeostasis of bacterial cells is maintained by coordinated processes of protein production, folding, and degradation. Translational efficiency of a given mRNA depends on how often the ribosomes initiate synthesis of a new polypeptide and how quickly they read the coding sequence to produce...

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Published inFrontiers in microbiology Vol. 11; p. 619430
Main Authors Samatova, Ekaterina, Daberger, Jan, Liutkute, Marija, Rodnina, Marina V
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 11.01.2021
Subjects
cotranslational folding
Microbiology
prokaryotes
ribosome pausing
translation
translation efficiency
tRNA
prokaryotes
tRNA
translation efficiency
translation
ribosome pausing
cotranslational folding
nascent peptide
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Summary:Protein homeostasis of bacterial cells is maintained by coordinated processes of protein production, folding, and degradation. Translational efficiency of a given mRNA depends on how often the ribosomes initiate synthesis of a new polypeptide and how quickly they read the coding sequence to produce a full-length protein. The pace of ribosomes along the mRNA is not uniform: periods of rapid synthesis are separated by pauses. Here, we summarize recent evidence on how ribosome pausing affects translational efficiency and protein folding. We discuss the factors that slow down translation elongation and affect the quality of the newly synthesized protein. Ribosome pausing emerges as important factor contributing to the regulatory programs that ensure the quality of the proteome and integrate the cellular and environmental cues into regulatory circuits of the cell.
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Edited by: Anna Maria Giuliodori, University of Camerino, Italy
Reviewed by: Martin Siemann-Herzberg, University of Stuttgart, Germany; Damon Huber, University of Birmingham, United Kingdom
This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2020.619430