Recent applications of immunomodulatory biomaterials for disease immunotherapy

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory effects of biomaterials themselves can...

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Published inExploration (Beijing, China) Vol. 2; no. 6; pp. 20210157 - n/a
Main Authors Dai, Huaxing, Fan, Qin, Wang, Chao
Format Journal Article
LanguageEnglish
Published China John Wiley & Sons, Inc 01.12.2022
John Wiley and Sons Inc
Wiley
Subjects
Adjuvants
Autoimmune diseases
Biomaterials
Biomedical materials
Cancer therapies
Coronaviruses
Cytokines
Dendritic cells
disease treatment
Drug delivery
Enzymes
Gold
Immune system
Immunomodulation
immunomodulatory effect
Immunotherapy
Infections
Inflammation
Inflammatory diseases
Iron
Malaria
Medical treatment
Nanomaterials
Nanoparticles
Physiology
Review
Reviews
Tumors
Vaccines
Viral infections
disease treatment
biomaterials
immunomodulatory effect
immunotherapy
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Summary:Immunotherapy is used to regulate systemic hyperactivation or hypoactivation to treat various diseases. Biomaterial‐based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory effects of biomaterials themselves cannot be neglected. In this review, we outline biomaterials with immunomodulatory functions discovered in recent years and their applications in disease treatment. These biomaterials can treat inflammation, tumors, or autoimmune diseases by regulating immune cell function, exerting enzyme‐like activity, neutralizing cytokines, etc. The prospects and challenges of biomaterial‐based modulation of immunotherapy are also discussed. Understanding the immunomodulatory functions of biomaterials themselves is critical for developing safe and effective immunotherapeutic platforms. This review summarizes some representative biomaterials with immunomodulatory functions discovered in recent years and their applications in therapy for inflammation, tumor, and autoimmune diseases, and discusses the challenges for the future development of biomaterials.
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ISSN:2766-8509
2766-2098
2766-2098
DOI:10.1002/EXP.20210157