Lipid Rafts and Assembly of Enveloped Viruses

The plasma membrane, late secretory pathway and endosomal compartments contain detergent‐insoluble raft microdomains that are enriched in sphingolipids and cholesterol. Rafts are currently an intensively studied topic of cell biology, and raft involvement has been implicated in numerous cellular pro...

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Bibliographic Details
Published inTraffic (Copenhagen, Denmark) Vol. 3; no. 10; pp. 705 - 709
Main Author Suomalainen, Maarit
Format Journal Article
LanguageEnglish
Published Oxford, UK Munksgaard International Publishers 01.10.2002
Subjects
assembly
budding
Ebola
HIV‐1
influenza
Lipid Metabolism
lipid rafts
Lipids - physiology
Medicin och hälsovetenskap
Membrane Proteins - metabolism
Virus Assembly
Virus Physiological Phenomena
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Summary:The plasma membrane, late secretory pathway and endosomal compartments contain detergent‐insoluble raft microdomains that are enriched in sphingolipids and cholesterol. Rafts are currently an intensively studied topic of cell biology, and raft involvement has been implicated in numerous cellular processes. A number of recent reports have localized structural proteins of several enveloped viruses to rafts, thus raising the possibility that rafts also play a role in the assembly and budding of viruses, but what exactly that role might be is still unknown.
Bibliography:ObjectType-Article-2
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ISSN:1398-9219
1600-0854
DOI:10.1034/j.1600-0854.2002.31002.x