Granisetron versus tropisetron in the prevention of postoperative nausea and vomiting after total thyroidectomy

• Published in: Saudi journal of anaesthesia Vol. 7; no. 1; pp. 68 - 74
• Main Authors: Papadima, Artemisia, Gourgiotis, Stavros, Lagoudianakis, Emmanuel, Pappas, Apostolos, Seretis, Charalampos, Antonakis, Pantelis, Markogiannakis, Haridimos, Makri, Ira, Manouras, Andreas
• Format: Journal Article
• Language: English
• Published: India Medknow Publications 01.01.2013; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Airway management; Anesthesia; Blood pressure; Drug dosages; Granisetron; Heart rate; Intubation; Nausea; Original; Patients; Pharmaceutical industry; Postoperative period; Surgery; thyroidectomy; tropisetron; Ventilation; vomiting; granisetron; thyroidectomy; Nausea; vomiting; tropisetron
• ISSN: 1658-354X; 0975-3125
• DOI: 10.4103/1658-354X.109817

Background: Postoperative nausea and vomiting (PONV) are frequently encountered after thyroidectomy. For PONV prevention, selective serotonin 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonists are considered one of the first-line therapy. We report on the efficiency of granisetron and tropisetron, with that of placebo on the prevention of PONV in patients undergoing total thyroidectomy. Methods: One hundred twenty-seven patients were divided into three groups and randomized to receive intravenously, prior to induction of anesthesia, tropisetron 5 mg, or granisetron 3 mg, or normal saline. All patients received additionally 0.625 mg droperidol. All episodes of postoperative PONV during the first 24 h after surgery were evaluated. Results: Nausea visual analogue scale (VAS) score was lower in tropisetron and granisetron groups than the control group at all measurements ( P<0.01) except for the 8-h measurement for tropisetron ( P=0.075). Moreover, granisetron performed better than tropisetron ( P<0.011 at 4 h and P<0.01 at all other points of time) apart from the 2-h measurement. Vomiting occurred in 22.2%, 27.5%, and 37.5% in granisetron, tropisetron, and control groups, respectively ( P=0.43). Conclusions: The combination of the 5-HT 3 antagonists with droperidol given before induction of anesthesia is well tolerated and superior to droperidol alone in preventing nausea but not vomiting after total thyroidectomy.