Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013

• Published in: Chinese medical journal Vol. 130; no. 17; pp. 2021 - 2026
• Main Authors: Peng, Ying, Chen, Song-Hua, Zhang, Le, Chen, Bin, Zhang, Ming-Wu, He, Tie-Niu, Wang, Fei, Chai, Cheng-Liang, Zhou, Lin, Zhang, Yu, Wang, Xiao-Meng, Jia, Zhongwei
• Format: Journal Article
• Language: English
• Published: China Medknow Publications and Media Pvt. Ltd 05.09.2017; Lippincott Williams & Wilkins Ovid Technologies; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China%National Institute of Drug Dependence, Peking University, Beijing 100191, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China%National Institute of Drug Dependence, Peking University, Beijing 100191, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Adolescent; Adult; Age groups; Analysis; Antitubercular Agents - therapeutic use; Child; Child, Preschool; China - epidemiology; Diagnosis; Disease control; Disease prevention; Drug resistance; Drug Resistance; Multidrug-resistant Tuberculosis Screening; Tuberculosis; Female; Health aspects; Health risk assessment; Humans; Infant; Infant, Newborn; Laboratories; Logistic Models; Male; Microbial drug resistance; Middle Aged; Multidrug resistant organisms; Observational studies; Original; Patients; Prevalence; Public health; Risk Factors; Trends; Tuberculosis; Tuberculosis - drug therapy; Tuberculosis - epidemiology; Tuberculosis, Multidrug-Resistant - drug therapy; Tuberculosis, Multidrug-Resistant - epidemiology; Young Adult; Drug Resistance; Tuberculosis; Multidrug-resistant Tuberculosis Screening
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.213413

Screening on multidrug-resistant tuberculosis (MDR-TB) has been limited to the serious TB subpopulations excluding the new TB patients. This study aimed to examine MDR-TB burden among the new TB patients. We conducted a study in Zhejiang Province during 2009-2013 to screen for MDR-TB patients among the low MDR-TB risk patients and five subpopulations of high MDR-TB risk patients. The number, prevalence, and trend of MDR-TB were compared while the logistic regression model was used to examine risk factors related to MDR-TB. A total of 200 and 791 MDR-TB cases were, respectively, identified from the 9830 new TB cases and 2372 high-risk suspects who took MDR-TB screening from 2009 to 2013. The MDR-TB rates went down in both of the new TB patients and five MDR-TB high-risk groups over the study time, but the percentage of MDR-TB patients identified from the new TB patients in all diagnosed MDR-TB cases kept stable from 28.3% in 2011 to 27.0% in 2012 to 26.0% in 2013. The study indicated that MDR-TB burden among new TB patients was high, thus screening for MDR-TB among the new TB patients should be recommended in China as well as in the similar situation worldwide.