A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

Abstract The pH-sensitive liposomes have been extensively used as an alternative to conventional liposomes in effective intracellular delivery of therapeutics/antigen/DNA/diagnostics to various compartments of the target cell. Such liposomes are destabilized under acidic conditions of the endocytoti...

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Bibliographic Details
Published inDrug delivery Vol. 22; no. 3; pp. 231 - 242
Main Authors Paliwal, Shivani Rai, Paliwal, Rishi, Vyas, Suresh P.
Format Journal Article
LanguageEnglish
Published England Informa Healthcare USA, Inc 01.05.2015
Informa Healthcare
Subjects
Chemotherapy
DNA - administration & dosage
DNA - genetics
Drug Carriers - chemistry
Drug Delivery Systems - methods
drug/gene delivery
fusogenicity
Gene Transfer Techniques
Humans
Hydrogen-Ion Concentration
intracellular delivery
Lipids - chemistry
Liposomes
pH-sensitive lipid
Pharmaceutical Preparations - administration & dosage
Polymers - chemistry
Theranostic Nanomedicine - methods
Chemotherapy
pH-sensitive lipid
drug/gene delivery
intracellular delivery
fusogenicity
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Summary:Abstract The pH-sensitive liposomes have been extensively used as an alternative to conventional liposomes in effective intracellular delivery of therapeutics/antigen/DNA/diagnostics to various compartments of the target cell. Such liposomes are destabilized under acidic conditions of the endocytotic pathway as they usually contain pH-sensitive lipid components. Therefore, the encapsulated content is delivered into the intracellular bio-environment through destabilization or its fusion with the endosomal membrane. The therapeutic efficacy of pH-sensitive liposomes enables them as biomaterial with commercial utility especially in cancer treatment. In addition, targeting ligands including antibodies can be anchored on the surface of pH-sensitive liposomes to target specific cell surface receptors/antigen present on tumor cells. These vesicles have also been widely explored for antigen delivery and serve as immunological adjuvant to enhance the immune response to antigens. The present review deals with recent research updates on application of pH-sensitive liposomes in chemotherapy/diagnostics/antigen/gene delivery etc.
Bibliography:ObjectType-Article-2
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ISSN:1071-7544
1521-0464
DOI:10.3109/10717544.2014.882469