Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

• Published in: Advances in polymer technology Vol. 2019; no. 2019; pp. 1 - 11
• Main Authors: Bukhari, Syed Nasir Abbas, Hussain, Syed Zajif, Ashraf, Muhammad Umer, Haseeb, Muhammad Tahir, Sher, Muhammad, Hussain, Muhammad Ajaz, Lodhi, Bilal Ahmad, Hussain, Irshad
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2019; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Biological products; Biomedical materials; Deionization; Diclofenac; Drug delivery systems; Drugs; Ethanol; Formulations; Hydrogels; Medical equipment; Moisture content; Pharmaceutical sciences; Pharmacy; Phase transitions; Physical properties; Polymers; Polysaccharides; Pore size; Porosity; Seeds; Stimuli; Sustained release; Swelling; Vehicles
• ISSN: 0730-6679; 1098-2329
• DOI: 10.1155/2019/9583516

This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swelling-deswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 μm noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic.