Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism

Myxobacteria are famous for their capacity for social behavior and natural product biosynthesis. The unique sociality of myxobacteria is not only an intriguing scientific topic but also the main limiting factor for their manipulation. After more than half a century of research, a series of genetic t...

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Bibliographic Details
Published inEngineering Microbiology Vol. 3; no. 2; p. 100075
Main Authors Yue, Xinjing, Sheng, Duohong, Zhuo, Li, Li, Yue-Zhong
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2023
Elsevier
Subjects
Epothilone
Genetic manipulation
Myxobacteria
Myxococcus xanthus
Review
Secondary metabolism
Genetic manipulation
Epothilone
Myxobacteria
Myxococcus xanthus
Secondary metabolism
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Summary:Myxobacteria are famous for their capacity for social behavior and natural product biosynthesis. The unique sociality of myxobacteria is not only an intriguing scientific topic but also the main limiting factor for their manipulation. After more than half a century of research, a series of genetic techniques for myxobacteria have been developed, rendering these mysterious bacteria manipulable. Here, we review the advances in genetic manipulation of myxobacteria, with a particular focus on the exploitation of secondary metabolism. We emphasize the necessity and urgency of constructing the myxobacterial chassis for synthetic biology research and the exploitation of untapped secondary metabolism. [Display omitted]
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ISSN:2667-3703
2097-4280
2667-3703
DOI:10.1016/j.engmic.2023.100075