Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study

Despite intensive treatment, 50% of children with high-risk neuroblastoma (HR-NB) succumb to their disease. Progression through current trials evaluating the efficacy of new treatments for children with HR disease usually depends on an inadequate response to induction chemotherapy, assessed using im...

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Published inCancers Vol. 11; no. 10; p. 1476
Main Authors Morini, Martina, Cangelosi, Davide, Segalerba, Daniela, Marimpietri, Danilo, Raggi, Federica, Castellano, Aurora, Fruci, Doriana, Font de Mora, Jaime, Cañete, Adela, Yáñez, Yania, Viprey, Virginie, Corrias, Maria Valeria, Carlini, Barbara, Pezzolo, Annalisa, Schleiermacher, Gudrun, Mazzocco, Katia, Ladenstein, Ruth, Sementa, Angela Rita, Conte, Massimo, Garaventa, Alberto, Burchill, Susan, Luksch, Roberto, Bosco, Maria Carla, Eva, Alessandra, Varesio, Luigi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 30.09.2019
MDPI
Subjects
Biomarkers
Biopsy
Cancer therapies
Chemoresistance
Chemotherapy
chemotherapy response
Children
Clinical trials
Exosomes
liquid biopsy
Metastasis
MicroRNAs
miRNA
Neuroblastoma
Patients
Plasma
Population
Tumor cells
Tumors
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Summary:Despite intensive treatment, 50% of children with high-risk neuroblastoma (HR-NB) succumb to their disease. Progression through current trials evaluating the efficacy of new treatments for children with HR disease usually depends on an inadequate response to induction chemotherapy, assessed using imaging modalities. In this study, we sought to identify circulating biomarkers that might be detected in a simple blood sample to predict patient response to induction chemotherapy. Since exosomes released by tumor cells can drive tumor growth and chemoresistance, we tested the hypothesis that exosomal microRNA (exo-miRNAs) in blood might predict response to induction chemotherapy. The exo-miRNAs expression profile in plasma samples collected from children treated in HR-NBL-1/SIOPEN before and after induction chemotherapy was compared to identify a three exo-miRs signature that could discriminate between poor and good responders. Exo-miRNAs expression also provided a chemoresistance index predicting the good or poor prognosis of HR-NB patients.
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The authors dedicate this article to the memory of Luigi Varesio, highly brilliant and inspiring scientist who, during the course of this study, passed away.
Deceased.
The authors contributed equally to this work.
The authors share senior authorship.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11101476