Biosynthesis of Chloro-β-Hydroxytyrosine, a Nonproteinogenic Amino Acid of the Peptidic Backbone of Glycopeptide Antibiotics

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Published inJournal of Bacteriology Vol. 186; no. 18; pp. 6093 - 6100
Main Authors PUK, Oliver, BISCHOLF, Daniel, KITTEL, Claudia, PELZER, Stefan, WEIST, Stefan, STEGMANN, Efthimia, SÜSSMUTH, Roderich D, WOHLLEBEN, Wolfgang
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2004
Subjects
Actinomycetales - genetics
Actinomycetales - metabolism
Amino acids
Amycolatopsis balhimycina
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
Antibiotics
Bacteria
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Bacteriology
Biological and medical sciences
Cytochrome P-450 Enzyme System - genetics
Cytochrome P-450 Enzyme System - metabolism
Dihydroxyphenylalanine - biosynthesis
Dihydroxyphenylalanine - metabolism
DNA, Bacterial - chemistry
Fundamental and applied biological sciences. Psychology
Gene Deletion
Genes
Genes, Bacterial
Genetic Complementation Test
Genetics and Molecular Biology
Mass Spectrometry
Microbiology
Miscellaneous
Molecular Sequence Data
Operon
Peptide Synthases - genetics
Peptides
Proteins
Sequence Analysis, DNA
Vancomycin - analogs & derivatives
Vancomycin - biosynthesis
Antibiotic
Biosynthesis
Microbiology
Glycopeptide
Bacteriology
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content type line 23
Present address: GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Entwicklungsgenetik, D-85764 Neuherberg, Germany.
Present address: Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Corresponding author. Mailing address: Mikrobiologie/Biotechnologie, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. Phone: 49 7071 2976944. Fax: 49 7071 295979. E-mail: wolfgang.wohlleben@biotech.uni-tuebingen.de.
Present address: Combinature Biopharm AG, D-13125 Berlin, Germany.
ISSN:0021-9193
1067-8832
1098-5530
DOI:10.1128/JB.186.18.6093-6100.2004