A Genomewide Search for Quantitative-Trait Loci Underlying Asthma

• Published in: American journal of human genetics Vol. 69; no. 6; pp. 1271 - 1277
• Main Authors: Xu, Xin, Fang, Zhian, Wang, Binyan, Chen, Changzhong, Guang, Wenwei, Jin, Yongtang, Yang, Jianghua, Lewitzky, Steve, Aelony, Avram, Parker, Alex, Meyer, Joanne, Weiss, Scott T., Xu, Xiping
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.12.2001; University of Chicago Press; The American Society of Human Genetics
• Subjects: Adult; Allergens - immunology; Animals; Antigens, Dermatophagoides; Asthma - blood; Asthma - chemically induced; Asthma - genetics; Asthma - immunology; Biological and medical sciences; Blattidae; Bronchoconstrictor Agents - pharmacology; China; chromosome 2; Chromosome Mapping; Chromosomes, Human - genetics; Chromosomes, Human, Pair 2 - genetics; Chronic obstructive pulmonary disease, asthma; Cockroaches - immunology; D10S1435 gene; D16S412 gene; D19S433 gene; D1S518 gene; D22S685 gene; D2S1780 gene; Eosinophils; Female; Forced Expiratory Volume - genetics; Genetic Linkage - genetics; Glycoproteins - immunology; Humans; Immunoglobulin E - blood; Immunoglobulin E - immunology; Leukocyte Count; Male; Medical sciences; methacholine; Methacholine Chloride - pharmacology; Phenotype; Pneumology; Quantitative Trait, Heritable; Skin Tests; Vital Capacity - genetics; China; China, People's Rep; Indication; IgE; Granulocyte; Blood; Specificity; Capacity; Bronchus disease; Genetics; Serum; Obstructive pulmonary disease; Quantitative analysis; Skin test; Lung disease; Linkage; Respiratory disease; Family study; Chromosome A2; Method; Eosinophil; Asthma; Phenotype; Reactivity; Volume; Chinese; Skin
• ISSN: 0002-9297; 1537-6605
• DOI: 10.1086/324650

A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC), airway responsiveness as indicated by methacholine (MTCH)-challenge test, serum total immunoglobulin E (TIgE), serum-specific immunoglobulin E, eosinophil count in peripheral blood, and skin-prick tests with three different allergens (cockroach, Dermatophagoides pteronyssinus, and D. farinae). Our study showed significant linkage between airway responsiveness to MTCH and D2S1780 on chromosome 2 ( P<.00002) and provided suggestive evidence ( P<.002) for six additional possible QTLs: D10S1435 and D22S685, for FEV 1; D16S412, for FVC; D19S433, for airway responsiveness to MTCH; D1S518, for TIgE; and D4S1647, for skin reactivity to cockroach. No significant or suggestive evidence of linkage for the other four traits was found.