Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice

The global population is aging and the prevalence of age-related diseases, such as Alzheimer's disease and vascular dementia is increasing. Understanding functional impairments and disease processes is of vital importance in order to develop effective therapeutics. Using the natural exploratory...

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Bibliographic Details
Published inBio-protocol Vol. 9; no. 3; p. e3162
Main Authors Prieur, Emily A K, Jadavji, Nafisa M
Format Journal Article
LanguageEnglish
Published United States Bio-Protocol 05.02.2019
Bio-protocol LLC
Subjects
Biology
Methods
Aging
Mouse
Spontaneous behavior
Spatial memory
Y-maze
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Summary:The global population is aging and the prevalence of age-related diseases, such as Alzheimer's disease and vascular dementia is increasing. Understanding functional impairments and disease processes is of vital importance in order to develop effective therapeutics. Using the natural exploratory behavior of mice, the spontaneous alternation y-maze can assess short-term spatial working memory. The protocol for y-maze testing is straightforward and requires minimal resources, as well as animal training and output. Therefore, it can be broadly applied to study short-term memory in aged rodent models.
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ISSN:2331-8325
2331-8325
DOI:10.21769/bioprotoc.3162