Feasibility of left ventricular volume measurements by three-dimensional speckle tracking echocardiography depends on image quality and degree of left ventricular enlargement: Validation study with cardiac magnetic resonance imaging

• Published in: Journal of cardiology Vol. 63; no. 3; pp. 230 - 238
• Main Authors: Kawamura, Ryo, Seo, Yoshihiro, Ishizu, Tomoko, Atsumi, Akiko, Yamamoto, Masayoshi, Machino-Ohtsuka, Tomoko, Nakajima, Hideki, Sakai, Satoshi, Tanaka, Yumiko Oishi, Minami, Manabu, Aonuma, Kazutaka
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2014
• Subjects: 3-Dimensional echocardiography; Adult; Aged; Cardiac Volume; Cardiovascular; Echocardiography, Three-Dimensional - methods; Feasibility Studies; Female; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Humans; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - pathology; Hypertrophy, Left Ventricular - physiopathology; Magnetic Resonance Imaging; Male; Middle Aged; Sensitivity and Specificity; Speckle tracking echocardiography; Ventricular function; Speckle tracking echocardiography; 3-Dimensional echocardiography; Ventricular function; Magnetic resonance imaging
• ISSN: 0914-5087; 1876-4738; 1876-4738
• DOI: 10.1016/j.jjcc.2013.08.010

Novel 3-dimensional echocardiography with speckle tracking imaging (3D-STE) may have advantages in assessing left ventricular (LV) volume through a cardiac cycle. The feasibility of 3D-STE may be affected by image quality and LV morphology. We studied 64 patients (38 men, age 55±12 years) who underwent cardiac magnetic resonance imaging (CMRI) and 3D-STE on the same day. LV end-diastolic volume (EDV) and end-systolic volume (ESV) were measured by both modalities. Imaging qualities were quantified in each of 6 LV segments by an imaging quality score (IQS) of 1–3, and scores were averaged (mean IQS) at end-diastole and end-systole. Compared to CMRI, 3D-STE showed a tendency to underestimate LV volume measurements, but not significantly (EDV: bias=−18±37ml; ESV: bias=−10±34ml), and measurements correlated well with those by CMRI (EDV: R=0.80, ESV: R=0.86, ejection fraction: R=0.75, p<0.001). The absolute differences of LVEDV and ESV between 3D-STE and CMRI correlated significantly with mean IQS (LVEDV, R=−0.35, p=0.005; LVESV, R=−0.30, p=0.02). Based on the medium value of LVEDV by CMRI (127ml), subjects were classified into the small (<127ml) and large LVEDV (≧127ml) groups. In the large LVEDV group, mean IQS significantly correlated with the absolute differences of LVEDV (mean IQS, r=−0.45, p=0.01), despite no significant correlation in the small LVEDV group. 3D-STE could measure LV volume as well as CMRI, however, its accuracy depends on the quality of the acquired image and particularly on enlargement of the left ventricle.