Carbapenem and Colistin Resistance in Enterobacter: Determinants and Clones

Enterobacter is a globally important pathogen. Here we clarify its taxonomy and review recent developments in its resistance to carbapenem and colistin, illustrating that Enterobacter has a large arsenal of mechanisms to grow under antimicrobial pressure. Further studies are required to decipher col...

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Published inTrends in microbiology (Regular ed.) Vol. 29; no. 6; pp. 473 - 476
Main Authors Zong, Zhiyong, Feng, Yu, McNally, Alan
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2021
Elsevier Science Ltd
Subjects
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
antimicrobial resistance
Bacterial Proteins - genetics
carbapenem resistance
carbapenems
Carbapenems - pharmacology
Colistin
Colistin - pharmacology
colistin resistance
Drug Resistance, Multiple, Bacterial
Enterobacter
Enterobacter - classification
Enterobacter - drug effects
Enterobacter - genetics
high-risk lineages
Humans
Microbial Sensitivity Tests
microbiology
pathogens
Taxonomy
colistin resistance
Enterobacter
taxonomy
carbapenem resistance
antimicrobial resistance
high-risk lineages
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Summary:Enterobacter is a globally important pathogen. Here we clarify its taxonomy and review recent developments in its resistance to carbapenem and colistin, illustrating that Enterobacter has a large arsenal of mechanisms to grow under antimicrobial pressure. Further studies are required to decipher colistin heteroresistance and understand why certain Enterobacter lineages have emerged clinically.
Bibliography:ObjectType-Article-1
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ISSN:0966-842X
1878-4380
1878-4380
DOI:10.1016/j.tim.2020.12.009