Clostridium perfringens Enterotoxin Damages the Human Intestine In Vitro

In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological...

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Published inInfection and Immunity Vol. 73; no. 12; pp. 8407 - 8410
Main Authors Fernández Miyakawa, M. E, Pistone Creydt, V, Uzal, F. A, McClane, B. A, Ibarra, C
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.12.2005
Subjects
Biological and medical sciences
Clostridium perfringens
Colon - drug effects
Colon - pathology
Enterotoxins - toxicity
Fundamental and applied biological sciences. Psychology
Humans
Ileum - drug effects
Ileum - pathology
In Vitro Techniques
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Microbiology
Molecular Pathogenesis
Human
Toxin
Microbiology
Digestive system
Clostridiaceae
Gut
Clostridiales
Enterotoxin
Bacteria
Immunity
Clostridium perfringens
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Summary:In vitro, Clostridium perfringens enterotoxin (CPE) binds to human ileal epithelium and induces morphological damage concurrently with reduced short-circuit current, transepithelial resistance, and net water absorption. CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant.
Bibliography:ObjectType-Article-1
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Editor: J. T. Barbieri
Corresponding author. Mailing address: California Animal Health and Food Safety Laboratory-San Bernardino Branch, University of California—Davis, 105 W. Central Avenue, San Bernardino, CA 92408. Phone: (909) 383-4287. Fax: (909) 884-5980. E-mail: mmiyakaw@cahfs.ucdavis.edu.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.12.8407-8410.2005