Complexation of Several Drugs with Water-Soluble Cyclodextrin Polymer

• Published in: Chemical & pharmaceutical bulletin Vol. 35; no. 1; pp. 282 - 288
• Main Authors: SZEMAN, JULIANNA, UEDA, HARUHISA, SZEJTLI, JOZSEF, FENYVESI, EVA, MACHIDA, YOSHIHARU, NAGAI, TSUNEJI
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.01.1987; Maruzen; Japan Science and Technology Agency
• Subjects: Biological and medical sciences; Cellulose - analysis; Chemical Phenomena; Chemistry; complexation; cyclodextrin polymer; Cyclodextrins - analysis; Dextrins - analysis; General pharmacology; Medical sciences; Pharmaceutical Preparations - analysis; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Solubility; solubility method; stability constant; Starch - analysis; Complexation; Stability; Solubility; Polymer; Inclusion compound; Molecular weight; Optimization; Gel permeation chromatography
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.35.282

The complex-forming abilities of a water-soluble β-cyclodextrin-epichlorohydrin polymer (CDPS) and two different molecular weight fractions of CDPS were studied and compared with those of β-cyclodextrin (β-CyD) and dimethyl-β-cyclodextrin (DM-β-CyD). CDPS was separated into two main fractions by gel chromatography. CDPS and its fractions formed inclusion compounds with several drugs and these complexes were readily soluble. The low-molecular-weight fraction formed rather stable complexes with small guest molecules. The high-molecular-weight fraction was found to be more efficient in binding larger substrates.