Pathophysiological Manifestations in Mice Exposed to Anthrax Lethal Toxin

Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrha...

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Bibliographic Details
Published inInfection and Immunity Vol. 73; no. 10; pp. 7006 - 7010
Main Authors Culley, Nathan C, Pinson, David M, Chakrabarty, Anuradha, Mayo, Matthew S, LeVine, Steven M
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2005
Subjects
Animals
Anthrax - blood
Anthrax - etiology
Anthrax - pathology
Antigens, Bacterial - toxicity
Bacterial Toxins - toxicity
Biological and medical sciences
Blood Vessels - physiopathology
Bronchi - pathology
Disseminated Intravascular Coagulation - microbiology
Disseminated Intravascular Coagulation - physiopathology
Fibrinogen - analysis
Fundamental and applied biological sciences. Psychology
Hemorrhage - microbiology
Hemorrhage - pathology
Hemorrhage - physiopathology
Host Response and Inflammation
Mice
Microbiology
Myocardium - chemistry
Myocardium - pathology
Bacillus anthracis
Microbiology
Rodentia
Bacillaceae
Immunity
Infection
Toxin
Vertebrata
Mammalia
Bacillales
Mouse
Anthrax
Bacteriosis
Bacteria
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Summary:Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Editor: J. T. Barbieri
Corresponding author. Mailing address: Mail Stop 1031, 3901 Rainbow Boulevard, KU Medical Center, Kansas City, KS 66160. Phone: (913) 588-7352. Fax: (913) 588-7277. E-mail: nculley@kumc.edu.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.10.7006-7010.2005