Research advances on the consolidated bioprocessing of lignocellulosic biomass

• Published in: Engineering Microbiology Vol. 4; no. 2; p. 100139
• Main Authors: Li, Zhongye, Waghmare, Pankajkumar R., Dijkhuizen, Lubbert, Meng, Xiangfeng, Liu, Weifeng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2024; Elsevier
• Subjects: Biochemicals; Biorefinery; Consolidated bioprocessing; Lignocellulosic biomass; Review; CBB; NRPs; AFEX; FPS; PHA; DMCC; PGASO; CBM; CBP; EGs; Ldh; CBHs; CBS; PEFA; Biochemicals; CMC; LPMOs; AECC; PYC; Consolidated bioprocessing; ED; ML; PASC; SECS; AI; MCC; Lignocellulosic biomass; ILs; XI; BGLs; XK; RAC; rTCA; SCFAs; Biorefinery; FAEE; Pta; TAL
• ISSN: 2667-3703; 2097-4280; 2667-3703
• DOI: 10.1016/j.engmic.2024.100139

•Lignocellulosic biomass is an abundant resource for the production of bioproducts.•The high cost of cellulase production is the main hurdle for biorefinery industry.•CBP is an alternative approach to classical biorefinery for biochemical production.•Bacteria, fungi and their co-culture are used for CBP lignocellulosic biorefinery. Lignocellulosic biomass is an abundant and renewable bioresource for the production of biofuels and biochemical products. The classical biorefinery process for lignocellulosic degradation and conversion comprises three stages, i.e., pretreatment, enzymatic saccharification, and fermentation. However, the complicated pretreatment process, high cost of cellulase production, and insufficient production performance of fermentation strains have restricted the industrialization of biorefinery. Consolidated bioprocessing (CBP) technology combines the process of enzyme production, enzymatic saccharification, and fermentation in a single bioreactor using a specific microorganism or a consortium of microbes and represents another approach worth exploring for the production of chemicals from lignocellulosic biomass. The present review summarizes the progress made in research of CBP technology for lignocellulosic biomass conversion. In this review, different CBP strategies in lignocellulose biorefinery are reviewed, including CBP with natural lignocellulose-degrading microorganisms as the chassis, CBP with biosynthetic microorganisms as the chassis, and CBP with microbial co-culturing systems. This review provides new perspectives and insights on the utilization of low-cost feedstock lignocellulosic biomass for production of biochemicals. [Display omitted]