Utility of Kyoto Classification of Gastritis in subjects with a high-negative titer of anti-Helicobacter pylori antibody during a medical check-up

• Published in: Journal of Clinical Biochemistry and Nutrition Vol. 67; no. 3; pp. 317 - 322
• Main Authors: Otani, Koji, Watanabe, Toshio, Kamata, Noriko, Nakata, Akinobu, Tanaka, Fumio, Nagami, Yasuaki, Kawada, Norifumi, Fukumoto, Shinya, Kosaka, Satoshi, Kimura, Tatsuo, Fujiwara, Yasuhiro, Fukunaga, Shusei, Matsumoto, Yuji, Taira, Koichi, Nadatani, Yuji, Tanigawa, Tetsuya, Hosomi, Shuhei
• Format: Journal Article
• Language: English
• Published: Gifu SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.11.2020; Japan Science and Technology Agency; the Society for Free Radical Research Japan
• Subjects: anti-H. pylori antibody; Antibodies; Antigens; Classification; Confidence intervals; Gastritis; Helicobacter pylori; high-negative titer; Infections; Kyoto Classification of Gastritis; medical check-up; Original; Regression analysis; Statistical analysis; Urea
• ISSN: 0912-0009; 1880-5086
• DOI: 10.3164/jcbn.20-21

Subjects with a high-negative titer (3–9.9 U/ml) of serum anti-Helicobacter pylori (H. pylori) antibody represent a heterogeneous group of currently H. pylori-infected, H. pylori-uninfected, and previously H. pylori-infected cases. We investigated the characteristics of subjects with a high-negative titer during a medical check-up and the utility of H. pylori infection score, the sum of scores of endoscopic findings based on the Kyoto Classification of Gastritis, for diagnosing H. pylori infection. Subjects with 13C-urea breath test-positive or H. pylori stool antigen test-positive were diagnosed as currently H. pylori-infected. Although around half of subjects with a high-negative titer were after eradication therapy (48.6%), currently H. pylori-infected were considerably confirmed (11.7%). H. pylori infection score showed a high value of area under the receiver operating characteristic curve [0.92; 95% confidence interval (CI), 0.84–1.00] with the most suitable cut-off value of 1.0 (sensitivity: 0.92; specificity: 0.90). Multivariate logistic regression analysis revealed that H. pylori infection score was an independent factor associated with increased prevalence of H. pylori infection (odds ratio, 9.53; 95% CI, 2.64–34.40; p<0.001). Currently H. pylori-infected subjects were considerably included among the subjects with a high-negative titer, and the Kyoto Classification of Gastritis was useful to predict current H. pylori infection.