Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 9; p. 1820
• Main Authors: Vall, Maria, Ferraz, Natalia, Cheung, Ocean, Strømme, Maria, Zardán Gómez de la Torre, Teresa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.05.2019; MDPI
• Subjects: Acne; amine functionalization; Cytotoxicity; Drug carriers; Drug delivery; drug release; Evaporation; Fibroblasts; Fungicides; Inflammation; Magnesium; Magnesium carbonate; mesoporous; Particle size; Porous materials; Salicylic acid; Skin diseases; Vibration; salicylic acid; drug release; amine functionalization; magnesium carbonate; cytotoxicity; mesoporous
• ISSN: 1420-3049; 1431-5157; 1420-3049
• DOI: 10.3390/molecules24091820

Salicylic acid (SA) has for a long time been used to treat various skin disorders due to its anti-inflammatory, bacteriostatic, and antifungal properties. In the present work, mesoporous magnesium carbonate (MMC), a promising drug carrier, was modified with 3-aminopropyl-triethoxysilane to enable loading of SA. The amine modified MMC (aMMC) was successfully loaded with 8 wt.% of SA via a solvent evaporation method. SA was later completely released from the carrier in less than 15 min. Furthermore, the cytotoxicity of the functionalized material was evaluated. aMMC was found to be non-toxic for human dermal fibroblast cells with particle concentration of up to 1000 µg/mL when exposed for 48 h. The presented results form the basis of future development of aMMC as a potential carrier for SA in dermatological applications.