Genetic markers linked to neuronal ceroid lipofuscinosis in English setter dogs
The neuronal ceroid lipofuscinoses (NCL) are a group of fatal autosomal recessive neurodegenerative diseases occurring in human and some domesticated animal species. A canine form of the disease (CNCL) has been extensively studied in a Norwegian colony of inbred English setters since 1960. A resourc...
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Published in | Animal genetics Vol. 29; no. 5; pp. 371 - 376 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.10.1998
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | The neuronal ceroid lipofuscinoses (NCL) are a group of fatal autosomal recessive neurodegenerative diseases occurring in human and some domesticated animal species. A canine form of the disease (CNCL) has been extensively studied in a Norwegian colony of inbred English setters since 1960. A resource family developed for genetic mapping and comprising 170 individuals was typed for 103 genetic markers. Linkage analysis showed three genetic markers to be linked to the disease locus with the closest marker at a distance of about 3 cm. Two other loci were linked with these markers making a linkage group of five genetic markers. The linkage group spanned a distance of 54 cm. Two genes for human forms of the disease, CLN2 and CLN3, have been identified and mapped to human chromosome 11p15 and 16p12, respectively. The present study did not indicate any linkage between CNCL and the canine CLN3 homologue or to homologues of markers for genes that map close to human CLN2. |
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Bibliography: | ark:/67375/WNG-RWM7J3P4-5 ArticleID:AGE358 istex:D9A5D3187D3FCFFFE351E5636BBA2A8AEE464228 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0268-9146 1365-2052 |
DOI: | 10.1046/j.1365-2052.1998.295358.x |