Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors

• Published in: Advanced science Vol. 10; no. 10; pp. e2205995 - n/a
• Main Authors: Bi, Jianling, Witt, Emily, Voltarelli, Vanessa A., Feig, Vivian R., Venkatachalam, Veena, Boyce, Hannah, McGovern, Megan, Gutierrez, Wade R., Rytlewski, Jeffrey D., Bowman, Kate R., Rhodes, Ashley C., Cook, Austin N., Muller, Benjamin N., Smith, Matthew G., Ramos, Alexis Rebecca, Panchal, Heena, Dodd, Rebecca D., Henry, Michael D., Mailloux, Adam, Traverso, Giovanni, Otterbein, Leo E., Byrne, James D.
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.04.2023; John Wiley and Sons Inc; Wiley
• Subjects: Cancer therapies; Chemotherapy; gas‐entrapping materials; Humans; Hydrogels; Hyperbaric Oxygenation; Hypoxia; Immunotherapy; malignant peripheral nerve sheath tumors; Nanoparticles; Neoplasms - drug therapy; Oxygen; Oxygen therapy; Polymers; Pressure vessels; Radiation; radiation therapy; Tumor Hypoxia; Tumor Microenvironment; Tumors; tumor hypoxia; gas-entrapping materials; malignant peripheral nerve sheath tumors; radiation therapy
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202205995

Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O2)‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O2‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors. A novel class of oxygen‐releasing materials is developed using molecular gastronomy techniques. Injection or implantation of these materials into tumors prolongs oxygen delivery to tumors and results in tumor hyperoxia, and in combination with radiation or chemotherapy this treatment significantly inhibits tumor growth and promotes survival.