Zolpidem and the risk of Parkinson's disease: A nationwide population-based study

• Published in: Journal of psychiatric research Vol. 58; pp. 84 - 88
• Main Authors: Yang, Yu-Wan, Hsieh, Teng-Fu, Yu, Chia-Hui, Huang, Yung-Sung, Lee, Ching-Chih, Tsai, Tsung-Huang
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Analysis of Variance; Biological and medical sciences; Cohort Studies; Community Health Planning; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Female; Humans; Hypnotics and Sedatives - adverse effects; Insomnia; Male; Medical sciences; Middle Aged; National Health Programs - statistics & numerical data; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Organic mental disorders. Neuropsychology; Parkinson Disease - epidemiology; Parkinson Disease - etiology; Parkinson's disease; Proportional Hazards Models; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Pyridines - adverse effects; Risk; Risk Factors; Sleep disturbance; Sleep Wake Disorders - drug therapy; Sleep Wake Disorders - epidemiology; Taiwan; Zolpidem; Taiwan; Sleep disturbance; Zolpidem; Risk; Parkinson's disease; Insomnia; Agonist; Nervous system diseases; Psychotropic; Gabaergic agonist; Parkinson disease; Sleep disorder; Hypnotic; Benzodiazepine receptor; Cerebral disorder; Imidazopyridine derivatives; Population-based survey; Central nervous system disease; Risk factor; Degenerative disease; Sedative; Neurological disorder; Gabaergic receptor A; Public health; Extrapyramidal syndrome

Abstract Background This nationwide population-based study investigated the risk of Parkinson's disease (PD) after zolpidem use in patients with sleep disturbance using the National Health Insurance Research Database (NHIRD) in Taiwan. Material and methods In total, 59,548 adult patients newly...